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Chemotherapy was potentiated by E7449 and single agent had important antitumor exercise in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile strains, probably by TNKS inhibition. According to this chance, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and noticeably alte